Seyed Abdulmajid Ayatollahi۱,۴, Farzad Kobarfard ۲, Shirin Moradkhani۳,*


۱Department of Pharmacognosy, School of pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

۲Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University ofMedical Sciences, Tehran, Iran

۳Department of Pharmacognosy, School of Pharmacy, Hamadan University of MedicalSciences, Hamadan, Iran

۴Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran,Iran


Asteraceae, the largest family of angiosperms, comprises about 1500 genera and 23000 species, distributed in three subfamilies and seventeen tribes. The genus Achillea is composed of 115 species of perennial herbs, all native to temperate regions of the northern hemisphere [1]. Aerial parts of different species of this genus are widely used in folk medicine for preparation of herbal teas with antiphlogistic and spasmolytic activity [2]. One document published about two centuries ago as Makhzan-Ol-Advieh, recommended it for bladder stone and urinary obstruction [3]. In recent studies, the extract of this genus exhibits pharmacological activities like anti-inflammatory and antiallergic [4], antihelmintic, cholagogue, antibacterial and antioxidant properties. Therefore, the many uses of Achillea species have created wide interest in their phytochemistry and Achillea tenuifolia Lam., a perennial herb, distributed in some regions of Iran [5] was candidate for phytochemical analysis. The methanolic extract of Achillea tenuifolia Lam. afforded a dichloromethane fraction from which Stearic acid, Lupeol, β-sitosterol, Methyl gallate, besides three flavones have been isolated for the first time and the structures of the isolated compounds were elucidated based on NMR (one dimensional and two dimensional techniques), IR and MS spectra. In case of salvigenin (one of the flavones) effect of solvent on ۱H-NMR spectra have been studied. Although considering the numerous uses of this genus in folk medicine, the antibacterial effect of plant in comparison with some antibiotics is under investigation and the preliminary results showed interesting results. Surprisingly, in some cases the extract has more activity than antibiotics.


[۱] Heywood VH. Flowering Plants of the World. BT Batsford Ltd, England (1998). [2] Ahmed AA, Gati T, Hussein TH, Ali AT, Tzakou OA, Couladis MA, Mabry TJ, Toth G: Tetrahedron. ۲۰۰۳, ۵۹: ۳۷۲۹ – ۳۷۳۵.

[۳] Khorasani A: Makhzan al-adviyah, Qarabadin el-Kabir. Tehran: Entesharatemahmoud. (1970) 110-111.

[۴]  Trifunovic S, Vajs V, Juranic Z, Zizak Z, Tesevic V, Macura S, Milosavljevic S. Cytotoxic constituents of Achilleaclavennae from Montenegro. Phytochemistry, ۲۰۰۶, ۶۷: ۸۸۷-۸۹۳.

GhahremanA.Flora of Iran .vol.15.Research Institute of Forests and Rangelands Publications, Tehran (2003). NO.1753.

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